Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct.
نویسندگان
چکیده
منابع مشابه
Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct.
Recent evidence has implicated endothelin-1 (ET-1) as an autocrine inhibitor of inner medullary collecting duct (IMCD) sodium and water transport. The regulators of IMCD ET-1 production are, however, largely unknown. Because of the unique hypertonic environment of the IMCD, the effect of varying extracellular tonicity on IMCD ET-1 production was evaluated. Increasing media osmolality from 300 t...
متن کاملEndothelin production by human inner medullary collecting duct cells.
T he inner medubbary collecting duct (IMCD) is the major nephron site of endothelin1 (ET1 ) production ( 1 ) in experimental animals. Subsequent studies have determined that ET1 binds to highdensity. high-affinity receptors on IMCD cells (2). resulting in potent inhibition of water transport (3) and Na/K ATPase activity (4). Hence, this peptide may function as an autocnine regulator of IMCD sod...
متن کاملFlow regulation of endothelin-1 production in the inner medullary collecting duct.
Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention. Extracellular fluid volume expansion increases collecting duct ET-1, thereby promoting natriuresis and diuresis; however, how this coupling between volume expansion and collecting duct ET-1 occurs is incompletely understood. One possibility...
متن کاملCalcium regulation of endothelin-1 synthesis in rat inner medullary collecting duct.
Collecting duct-derived endothelin-1 (ET-1) reduces blood pressure and inhibits Na and water reabsorption. Collecting duct ET-1 production is increased by volume expansion; however, the mechanism by which this occurs is unknown. We hypothesized that intracellular calcium, which is likely to be increased by volume expansion, regulates collecting duct ET-1 synthesis. Rat inner medullary collectin...
متن کاملEndothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways.
Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated cAMP accumulation in the collecting duct has been hypothesized to be mediated, at least in part, by nitric oxide (NO). To examine this, the effect of ET-1 on NO production by acutely isolated rat inner medullary collecting duct (IMCD) cell suspensions and the role of NO in mediating ET-1 effects on AVP-stimulated cAMP accumulation w...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1993
ISSN: 0021-9738
DOI: 10.1172/jci116286